The human genome project yielded the sequences of over 20,000 proteins. Elucidating the roles these proteins play in health and disease, and also how they can be used and/or modified for the development of novel therapeutics, biomaterials, biosensors, methods for energy production and methods for environmental remediation, will be aided by a better understanding of how a protein's amino acid sequence determines its structure and how structure determines function.  Members of the Jeffery lab are using biophysical and biochemical methods along with computer-based structure analysis in several projects to study the connections between protein sequences, structures, and functions.  Current research topics include moonlighting proteins, pseudoenzymes, and proteins involved in cancer and IBD.