The human genome project yielded the sequences of over 20,000 proteins. Elucidating the roles these proteins play in health and disease, and also how they can be used and/or modified for the development of novel therapeutics, biomaterials, biosensors, methods for energy production and methods for environmental remediation, will be aided by a better understanding of how a protein's amino acid sequence determines its structure and how structure determines function.  Members of the Jeffery lab are using biophysical and biochemical methods along with computer-based structure analysis in several projects to study the connections between protein sequences, structures, and functions.  Current research topics include moonlighting proteins, pseudoenzymes, metamorphic proteins and proteins involved in cancer and IBD.