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Publications
Curtis NJ, Patel KJ, Rizwan A, Jeffery CJ. Moonlighting Proteins: Diverse Functions Found in Fungi. J Fungi (Basel). 2023 Nov 15;9(11):1107. doi: 10.3390/jof9111107. PMID: 37998912; PMCID: PMC10672435.
Jeffery CJ. Current successes and remaining challenges in protein function prediction. Front Bioinform. 2023 Jul 27;3:1222182. doi: 10.3389/fbinf.2023.1222182. PMID: 37576715; PMCID: PMC10415035.
Jeffery CJ, MSFP: Undergraduate “Collaborate from Home” Research in Macromolecular Structure and Function, Bioinformatics Advances, 2023;, vbad074, https://doi.org/10.1093/bioadv/vbad074
Jeffery CJ. Updating MoonProt From Home: An Online Student Research Project During the COVID-19 Pandemic The Biophysicist 2021 2 (2): 23–27.
Curtis NJ, Jeffery CJ. The expanding world of metabolic enzymes moonlighting as RNA binding proteins. Biochem Soc Trans. 2021 Jun 30;49(3):1099-1108. doi: 10.1042/BST20200664. PMID: 34110361
Jeffery CJ, Dorgan KM, Pysh L. Promoting a more integrated approach to structure and function. Integr Comp Biol. 2021 Jun 28;. doi: 10.1093/icb/icab144. PMID: 34180524.
Chen C, H Liu, S Zabad, N Rivera, E Rowin, M Hassan, SM Gomez De Jesus, PS Llinás Santos, K Kravchenko, M Mikhova, S Ketterer, A Shen, S Shen, E Navas, B Horan, J Raudsepp, CJ Jeffery (2021) MoonProt 3.0: an update of the moonlighting proteins database, Nucleic Acids Research, gkaa1101,https://doi.org/10.1093/nar/gkaa1101
Liu H, and CJ Jeffery. (2020) Moonlighting Proteins in the Fuzzy Logic of Cellular Metabolism. Molecules. 25(15):3440. doi: 10.3390/molecules25153440. PMID: 32751110; PMCID: PMC7435893.
Jeffery CJ. (2020) Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies. FEBS J. 287(19):4141-4149. doi: 10.1111/febs.15446. PMID: 32534477.
Chen Q, R Britto, I Erill, CJ Jeffery, A Liberzon, M Magrane, JI Onami, M Robinson-Rechavi, J Sponarova, J Zobel, K Verspoor. (2020) Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases. Genomics Proteomics Bioinformatics. 18(2):91-103. doi: 10.1016/j.gpb.2018.11.006. PMID: 32652120.
Jeffery CJ. (2019) An enzyme in the test tube, and a transcription factor in the cell: moonlighting proteins and cellular factors that affect their behavior. Protein Sci. 2019 May 14. doi: 10.1002/pro.3645.
Jeffery CJ. (2019) Multitalented actors inside and outside the cell: recent discoveries add to the number of moonlighting proteins. Biochem Soc Trans. 47(6):1941-1948. doi: 10.1042/BST20190798. PMID: 31803903.
Jeffery CJ. (2019) The demise of catalysis, but new functions arise: pseudoenzymes as the phoenixes of the protein world. Biochem Soc Trans. 47(1):371-379. doi: 10.1042/BST20180473.
Jeffery CJ. (2019) Intracellular/surface moonlighting proteins that aid in the attachment of gut microbiota to the host. AIMS Microbiology 5(1): 77-86. doi: 10.3934/microbiol.2019.1.77
Zhou N, Jiang Y, Bergquist TR, Lee AJ, Kacsoh BZ, Crocker AW, Lewis KA, Georghiou G, Nguyen HN, Hamid MN, Davis L, Dogan T, Atalay V, Rifaioglu AS, Dalkıran A, Cetin Atalay R, Zhang C, Hurto RL, Freddolino PL, Zhang Y, Bhat P, Supek F, Fernández JM, Gemovic B, Perovic VR, Davidović RS, Sumonja N, Veljkovic N, Asgari E, Mofrad MRK, Profiti G, Savojardo C, Martelli PL, Casadio R, Boecker F, Schoof H, Kahanda I, Thurlby N, McHardy AC, Renaux A, Saidi R, Gough J, Freitas AA, Antczak M, Fabris F, Wass MN, Hou J, Cheng J, Wang Z, Romero AE, Paccanaro A, Yang H, Goldberg T, Zhao C, Holm L, Törönen P, Medlar AJ, Zosa E, Borukhov I, Novikov I, Wilkins A, Lichtarge O, Chi PH, Tseng WC, Linial M, Rose PW, Dessimoz C, Vidulin V, Dzeroski S, Sillitoe I, Das S, Lees JG, Jones DT, Wan C, Cozzetto D, Fa R, Torres M, Warwick Vesztrocy A, Rodriguez JM, Tress ML, Frasca M, Notaro M, Grossi G, Petrini A, Re M, Valentini G, Mesiti M, Roche DB, Reeb J, Ritchie DW, Aridhi S, Alborzi SZ, Devignes MD, Koo DCE, Bonneau R, Gligorijević V, Barot M, Fang H, Toppo S, Lavezzo E, Falda M, Berselli M, Tosatto SCE, Carraro M, Piovesan D, Ur Rehman H, Mao Q, Zhang S, Vucetic S, Black GS, Jo D, Suh E, Dayton JB, Larsen DJ, Omdahl AR, McGuffin LJ, Brackenridge DA, Babbitt PC, Yunes JM, Fontana P, Zhang F, Zhu S, You R, Zhang Z, Dai S, Yao S, Tian W, Cao R, Chandler C, Amezola M, Johnson D, Chang JM, Liao WH, Liu YW, Pascarelli S, Frank Y, Hoehndorf R, Kulmanov M, Boudellioua I, Politano G, Di Carlo S, Benso A, Hakala K, Ginter F, Mehryary F, Kaewphan S, Björne J, Moen H, Tolvanen MEE, Salakoski T, Kihara D, Jain A, Šmuc T, Altenhoff A, Ben-Hur A, Rost B, Brenner SE, Orengo CA, Jeffery CJ, Bosco G, Hogan DA, Martin MJ, O'Donovan C, Mooney SD, Greene CS, Radivojac P, Friedberg I. (2019) The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biology 20(1):244. doi: 10.1186/s13059-019-1835-8.
Chen C and CJ Jeffery. (2019) Moonlighting Functions of Heat Shock Protein 90. In “Heat Shock Protein 90 in Human Diseases and Disorders” Prof. Dr. Alexzander A. A. Asea and Dr. Punit Kaur, editors, Volume 19 in the book series Heat Shock Proteins; Springer Nature Publishers (Dordrecht, Netherlands). https://doi.org/10.1007/978-3-030-23158-3_13
Jeffery CJ. (2019) The use of proteomics studies in identifying moonlighting proteins in Functional Proteomics: Methods and Protocols eds. Xing Wang, and Mattrew Kuruc, Springer Science and Business Media, LLC, New York. 437-443.
Jeffery CJ. (2018) Intracellular proteins moonlighting as bacterial adhesion factors. AIMS Microbiology. 4(2): 362–376. DOI: 10.3934/microbiol.2018.2.362
Bhatt F, V Patel, CJ Jeffery. (2018) Open Conformation of the Escherichia coli Periplasmic Murein Tripeptide Binding Protein, MppA, at High Resolution. Biology (Basel). 7(2). pii: E30. doi: 10.3390/biology7020030. PMID: 29783769
Chen C, S Zabad, H Liu, W Wang, CJ Jeffery (2018) MoonProt 2.0: an expansion and update of the moonlighting proteins database. Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D640–D644, https://doi.org/10.1093/nar/gkx1043
Jeffery CJ. (2018) Protein moonlighting: What is it, and why is it important. Philosophical Transactions of the Royal Society B. Jan 19;373(1738). pii: 20160523. doi: 10.1098/rstb.2016.0523. PMID:29203708
C. J. Jeffery. (2017) Moonlighting Proteins - Nature’s Swiss Army Knives. Science Progress. Nov 17;100(4):363-373. doi: 10.3184/003685017X15063357842574. PMID: 29113626
Jeffery CJ. (2017) Keeping good friends close - The surface and secreted proteomes of a probiotic bacterium provide candidate proteins for intestinal attachment and communication with the host. Proteomics. 17(11). doi: 10.1002/pmic.201700112. PMID: 28517912
C. J. Jeffery. (2017) Moonlighting Proteins In Bacteria. in Moonlighting Proteins: Novel Virulence Factors in Bacterial Infection. (B. Henderson, Ed.) Springer (Netherlands). In Press.
W. Wang and C. J. Jeffery. (2016) An Analysis of Surface Proteomics Results Reveals Novel Candidates for Intracellular/Surface Moonlighting Proteins in Bacteria. Mol Biosyst. 2016 Apr 26;12(5):1420-31. doi: 10.1039/c5mb00550g. PMID: 26938107
C. J. Jeffery. (2016) Expression, Solubilization and Purification of Bacterial Membrane Proteins. Current Protocols in Protein Science. 83:29.15.1-29.15.15. doi: 10.1002/0471140864.ps2915s83
C. J. Jeffery. (2016) Protein Species and Moonlighting Proteins: Very Small Changes in a Protein’s Covalent Structure Can Change its Biochemical Function. Journal of Proteomics. pii: S1874-3919(15)30146-9. doi: 10.1016/j.jprot.2015.10.003.
Mani, M. C. Chen, V. Amblee, H. Liu, T. Mathur, G. Zwicke, S. Zabad, B. Patel, J. Thakkar, and C. J. Jeffery. (2015) Moonlighting Proteins Database (MoonProt): A database of proteins that are known to moonlight. Nucleic Acids Research. 43: D277–D282. doi: 10.1093/nar/gku954. PMID: 25324305
Jeffery, C. J. (2015) Pancreatic Cancer, Islet Cell. in The SAGE Encyclopedia of Cancer and Society, Second Edition, editors Colditz, Graham A., Golson, J. Geoffrey. SAGE Publications, Inc. Thousand Oaks, California. pp 891-893 http://dx.doi.org/10.4135/9781483345758.n438
C. J. Jeffery. (2015) Why Study Moonlighting Proteins? Frontiers in Genetics. Research Topic on Moonlighting Proteins. 6:211. doi:10.3389/fgene.2015.00211. PMID: 26150826
Amblee, V. and C. J. Jeffery. (2015) Physical Features of Intracellular Proteins that Moonlight on the Cell Surface. PLOS One. 10(6):e0130575. doi: 10.1371/journal.pone.0130575. eCollection 2015. PMID: 26110848
Jeffery, C. J. (2015) Lung Cancer, Small Cell. in The SAGE Encyclopedia of Cancer and Society, Second Edition, editors Colditz, Graham A., Golson, J. Geoffrey. SAGE Publications, Inc. Thousand Oaks, California. pp 697-698. http://dx.doi.org/10.4135/9781483345758.n339
Jeffery, C. J. (2014) An Introduction to Moonlighting Proteins. Biochemistry Society Transactions. 42(6):1679-1683.
Jeffery C.J. (2013) "New Ideas on Moonlighting", in Moonlighting Cell Stress Proteins in Microbial Infections (B. Henderson, Ed.) Springer (Netherlands). ISBN: 978-94-007-6786-7 (Print) 978-94-007-6787-4 (Online) doi. 10.1007/978-94-007-6787-4. pp. 51-66.
Zwicke, G. L., G. A. Mansoori and C. J. Jeffery. (2012) Utilizing the Folate Receptor for Active Targeting of Cancer Nanotherapeutics. Nano Rev. 2012;3. doi: 10.3402/nano.v3i0.18496. PMID: 23240070
Jeffery, C. J. (2012) Workshop Attendees Suggest Methods to Improve the Number and Advancement of Women Scientists in Nanoscience/Nanotechnology. Nano Reviews. 3: 15895. (News Article for “Nano News and Nano Views” section in Nano Reviews)
Jeffery, C. J. (2012) Danish Team wins First BIOMOD International Undergraduate Nanobiology Design Competition. Nano Reviews. 3: 17201. (News Article for “Nano News and Nano Views” section in Nano Reviews)
Roux, C., F. Bhatt, J. Foret, B. de Courcy, N. Gresh, J.-P. Piquemal, C. J. Jeffery, and L. Salmon. (2011) The reaction mechanism of type I phosphomannose isomerases: new information from inhibition and polarizable molecular mechanics studies.
Proteins: Structure, Function, and Bioinformatics 79: 203-220.
Jeffery, C. J. (2011) Proteins with Neomorphic Moonlighting Functions in Disease. IUBMB Life (Special issue with the topic Moonlighting Proteins in Neurological Disorders). 63(7): 489-94.
Jeffery, C. J. (2011) Engineering Perplasmic Binding Proteins as Glucose Nanosensors. Nano Reviews 2: 5743-6. doi: 10.3402/nano.v2i0.5743. PMID: 22110874.
Bhatt, F. and C. J. Jeffery (2010) Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein. J Vis Exp. Dec 3;(46). pii: 2134. doi: 10.3791/2134.
Madhavan, V, F. Bhatt, and C. J. Jeffery. (2010) Recombinant expression screening of P. aeruginosa bacterial inner membrane proteins. BMC Biotechnol. 10:83.
Arsenieva, D., B. L. Appavu, G. Mazock, and C. J. Jeffery. (2009) X-ray Crystal Structure of Trypanosoma brucei Phosphoglucose Isomerase Complexed with Glucose-6-phosphate at 1.6 Å Resolution. Proteins: Structure, Function, and Bioinformatics 74:72-80
Jeffery, C. J. (2009) Moonlighting Proteins - An Update. Molecular Biosystems. 5:345-50.
Jeffery, C. J. (2007) Review of New and Emerging Proteomic Techniques by Dobrin Nedelko and Randall W. Nelson. J Am Soc Mass Spectrom 18:162–164.
Jeffery, C. J. (2005) Mass Spectrometry and the Search for Moonlighting Proteins. Mass Spectrometry Reviews. 24:772-82.
Jeffery, C. J. (2005) Moonlighting Proteins: Proteins with Multiple Functions. In The Extracellular Biology of Molecular Chaperones. Edited by Brian Henderson and A. Graham Pockley. Cambridge University Press. New York. Pp. 61-77.
Lee, J.H. and C. J. Jeffery. (2005) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with D-Sorbitol-6-phosphate, an Analog of the Open Chain Form of D-glucose-6-phosphate. Protein Science. 14: 727-34.
Jeffery, C. J. (2004) Moonlighting Proteins: Complications and Implications for Proteomics Research. Drug Discovery Today Targets. 3: 71-78.
Jeffery, C. J. (2004) Molecular Mechanisims of Multitasking: Recent Crystal Structures of Moonlighting Proteins. Current Opinion in Structural Biology. 14: 663-8.
Roux, C., J. H. Lee, C. J. Jeffery, and L. Salmon. (2004) Inhibition of type I and type II Phosphomannose Isomerases by the Reaction Intermediate Analogue 5‑phospho-D-arabinonohydroxamic Acid Supports a Catalytic Role for the Metal Cofactor. Biochemistry. 43: 2926-34.
Jeffery, C. J. (2003) Moonlighting Proteins: Old Proteins Learning New Tricks. Trends in Genetics. 19: 415-7.
Jeffery, C. J. (2003) Multifunctional Proteins: Examples of Gene Sharing. Annals of Medicine. 35: 28-35.
Arsenieva, D. and C. J. Jeffery. (2002) Conformational Changes in Phosphoglucose Isomerase Induced by Ligand Binding. Journal of Molecular Biology. 323: 77-84
Arsenieva, D., R. Hardré, L. Salmon, and C. J. Jeffery. (2002) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with 5-phospho-D-arabinonhydroxamate. Proc. Nat. Acad. Sci., USA. 99: 5872-7.
Lee, J.H., K.Z. Chang, V. Patel, and C. J. Jeffery (2001) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with its Substrate, D-Fructose 6-Phosphate. Biochemistry, 40:7799-805.
Jeffery, C. J., R. Hardré, and L. Salmon. (2001) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with 5-Phospho-D-Arabinonate Identifies the Role of Glu357 in Catalysis. Biochemistry. 40: 1560-6.
Jeffery, C. J., B. Bahnson, W. Chien, D. Ringe, and G. A. Petsko. (2000) Crystal Structure of Rabbit Phosphoglucose Isomerase, a Glycolytic Enzyme that Moonlights as Neuroleukin, Autocrine Motility Factor, and Differentiation Mediator. Biochemistry. 39: 955-64.
Jeffery, C. J., L.M. Gloss, G. A. Petsko, and D. Ringe. (2000) The Role of Resides Outside of the Active Site in Catalysis: Structural basis for function of C191 mutants of E. coli Aspartate Aminotransferase. Protein Engineering. 13: 105-12.
Jeffery, C. J. Moonlighting Proteins. (1999) Trends in Biochemical Sciences. 24: 8-11.
Jeffery, C. J. and D. E. Koshland, Jr. (1999) The E. coli Aspartate Receptor: Sequence Specificity of a Transmembrane Helix Studied by Hydrophobic-Biased Random Mutagenesis. Protein Engineering. 12: 863-72.
Jeffery, C. J., T. Barry, S. Doonan, G. A. Petsko, and D. Ringe. (1998) Crystal Structure of Saccharomyces cerevisiae Cytosolic Aspartate Aminotransferase. Protein Science. 7: 1380-7.
Jeffery, C. J., T. Barry, S. Doonan, G. A. Petsko, and D. Ringe. (1998) Crystallization and Preliminary X-ray Diffraction Analysis of S. cerevisiae Aspartate Aminotransferase. Acta Cryst D54: 659-61.
Jeffery, C. J. and D. E. Koshland, Jr. (1994) A Single Hydrophobic to Hydrophobic Substitution in the Transmembrane Domain Impairs Aspartate Receptor Function. Biochemistry. 33: 3457-63.
Jeffery, C. J. and D. E. Koshland, Jr. (1993) Vibrio cholerae hlyB is a Member of the Chemotaxis Receptor Gene Family. Protein Science. 2: 1532-5.
Jeffery, C. J. and D. E. Koshland, Jr. (1993) Three-dimensional Structural Model of the Serine Receptor Ligand-Binding Domain. Protein Science. 2: 559-66.
Lynch, B. A., C. J. Jeffery, H.-P. Biemann, and D. E. Koshland, Jr. (1992) Transmembrane Signaling in the Bacterial Aspartate Receptor. Proceedings of the Robert A. Welch Foundation Conference on Chemical Research. XXXVI.
Jeffery CJ. Current successes and remaining challenges in protein function prediction. Front Bioinform. 2023 Jul 27;3:1222182. doi: 10.3389/fbinf.2023.1222182. PMID: 37576715; PMCID: PMC10415035.
Jeffery CJ, MSFP: Undergraduate “Collaborate from Home” Research in Macromolecular Structure and Function, Bioinformatics Advances, 2023;, vbad074, https://doi.org/10.1093/bioadv/vbad074
Jeffery CJ. Updating MoonProt From Home: An Online Student Research Project During the COVID-19 Pandemic The Biophysicist 2021 2 (2): 23–27.
Curtis NJ, Jeffery CJ. The expanding world of metabolic enzymes moonlighting as RNA binding proteins. Biochem Soc Trans. 2021 Jun 30;49(3):1099-1108. doi: 10.1042/BST20200664. PMID: 34110361
Jeffery CJ, Dorgan KM, Pysh L. Promoting a more integrated approach to structure and function. Integr Comp Biol. 2021 Jun 28;. doi: 10.1093/icb/icab144. PMID: 34180524.
Chen C, H Liu, S Zabad, N Rivera, E Rowin, M Hassan, SM Gomez De Jesus, PS Llinás Santos, K Kravchenko, M Mikhova, S Ketterer, A Shen, S Shen, E Navas, B Horan, J Raudsepp, CJ Jeffery (2021) MoonProt 3.0: an update of the moonlighting proteins database, Nucleic Acids Research, gkaa1101,https://doi.org/10.1093/nar/gkaa1101
Liu H, and CJ Jeffery. (2020) Moonlighting Proteins in the Fuzzy Logic of Cellular Metabolism. Molecules. 25(15):3440. doi: 10.3390/molecules25153440. PMID: 32751110; PMCID: PMC7435893.
Jeffery CJ. (2020) Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies. FEBS J. 287(19):4141-4149. doi: 10.1111/febs.15446. PMID: 32534477.
Chen Q, R Britto, I Erill, CJ Jeffery, A Liberzon, M Magrane, JI Onami, M Robinson-Rechavi, J Sponarova, J Zobel, K Verspoor. (2020) Quality Matters: Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases. Genomics Proteomics Bioinformatics. 18(2):91-103. doi: 10.1016/j.gpb.2018.11.006. PMID: 32652120.
Jeffery CJ. (2019) An enzyme in the test tube, and a transcription factor in the cell: moonlighting proteins and cellular factors that affect their behavior. Protein Sci. 2019 May 14. doi: 10.1002/pro.3645.
Jeffery CJ. (2019) Multitalented actors inside and outside the cell: recent discoveries add to the number of moonlighting proteins. Biochem Soc Trans. 47(6):1941-1948. doi: 10.1042/BST20190798. PMID: 31803903.
Jeffery CJ. (2019) The demise of catalysis, but new functions arise: pseudoenzymes as the phoenixes of the protein world. Biochem Soc Trans. 47(1):371-379. doi: 10.1042/BST20180473.
Jeffery CJ. (2019) Intracellular/surface moonlighting proteins that aid in the attachment of gut microbiota to the host. AIMS Microbiology 5(1): 77-86. doi: 10.3934/microbiol.2019.1.77
Zhou N, Jiang Y, Bergquist TR, Lee AJ, Kacsoh BZ, Crocker AW, Lewis KA, Georghiou G, Nguyen HN, Hamid MN, Davis L, Dogan T, Atalay V, Rifaioglu AS, Dalkıran A, Cetin Atalay R, Zhang C, Hurto RL, Freddolino PL, Zhang Y, Bhat P, Supek F, Fernández JM, Gemovic B, Perovic VR, Davidović RS, Sumonja N, Veljkovic N, Asgari E, Mofrad MRK, Profiti G, Savojardo C, Martelli PL, Casadio R, Boecker F, Schoof H, Kahanda I, Thurlby N, McHardy AC, Renaux A, Saidi R, Gough J, Freitas AA, Antczak M, Fabris F, Wass MN, Hou J, Cheng J, Wang Z, Romero AE, Paccanaro A, Yang H, Goldberg T, Zhao C, Holm L, Törönen P, Medlar AJ, Zosa E, Borukhov I, Novikov I, Wilkins A, Lichtarge O, Chi PH, Tseng WC, Linial M, Rose PW, Dessimoz C, Vidulin V, Dzeroski S, Sillitoe I, Das S, Lees JG, Jones DT, Wan C, Cozzetto D, Fa R, Torres M, Warwick Vesztrocy A, Rodriguez JM, Tress ML, Frasca M, Notaro M, Grossi G, Petrini A, Re M, Valentini G, Mesiti M, Roche DB, Reeb J, Ritchie DW, Aridhi S, Alborzi SZ, Devignes MD, Koo DCE, Bonneau R, Gligorijević V, Barot M, Fang H, Toppo S, Lavezzo E, Falda M, Berselli M, Tosatto SCE, Carraro M, Piovesan D, Ur Rehman H, Mao Q, Zhang S, Vucetic S, Black GS, Jo D, Suh E, Dayton JB, Larsen DJ, Omdahl AR, McGuffin LJ, Brackenridge DA, Babbitt PC, Yunes JM, Fontana P, Zhang F, Zhu S, You R, Zhang Z, Dai S, Yao S, Tian W, Cao R, Chandler C, Amezola M, Johnson D, Chang JM, Liao WH, Liu YW, Pascarelli S, Frank Y, Hoehndorf R, Kulmanov M, Boudellioua I, Politano G, Di Carlo S, Benso A, Hakala K, Ginter F, Mehryary F, Kaewphan S, Björne J, Moen H, Tolvanen MEE, Salakoski T, Kihara D, Jain A, Šmuc T, Altenhoff A, Ben-Hur A, Rost B, Brenner SE, Orengo CA, Jeffery CJ, Bosco G, Hogan DA, Martin MJ, O'Donovan C, Mooney SD, Greene CS, Radivojac P, Friedberg I. (2019) The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biology 20(1):244. doi: 10.1186/s13059-019-1835-8.
Chen C and CJ Jeffery. (2019) Moonlighting Functions of Heat Shock Protein 90. In “Heat Shock Protein 90 in Human Diseases and Disorders” Prof. Dr. Alexzander A. A. Asea and Dr. Punit Kaur, editors, Volume 19 in the book series Heat Shock Proteins; Springer Nature Publishers (Dordrecht, Netherlands). https://doi.org/10.1007/978-3-030-23158-3_13
Jeffery CJ. (2019) The use of proteomics studies in identifying moonlighting proteins in Functional Proteomics: Methods and Protocols eds. Xing Wang, and Mattrew Kuruc, Springer Science and Business Media, LLC, New York. 437-443.
Jeffery CJ. (2018) Intracellular proteins moonlighting as bacterial adhesion factors. AIMS Microbiology. 4(2): 362–376. DOI: 10.3934/microbiol.2018.2.362
Bhatt F, V Patel, CJ Jeffery. (2018) Open Conformation of the Escherichia coli Periplasmic Murein Tripeptide Binding Protein, MppA, at High Resolution. Biology (Basel). 7(2). pii: E30. doi: 10.3390/biology7020030. PMID: 29783769
Chen C, S Zabad, H Liu, W Wang, CJ Jeffery (2018) MoonProt 2.0: an expansion and update of the moonlighting proteins database. Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D640–D644, https://doi.org/10.1093/nar/gkx1043
Jeffery CJ. (2018) Protein moonlighting: What is it, and why is it important. Philosophical Transactions of the Royal Society B. Jan 19;373(1738). pii: 20160523. doi: 10.1098/rstb.2016.0523. PMID:29203708
C. J. Jeffery. (2017) Moonlighting Proteins - Nature’s Swiss Army Knives. Science Progress. Nov 17;100(4):363-373. doi: 10.3184/003685017X15063357842574. PMID: 29113626
Jeffery CJ. (2017) Keeping good friends close - The surface and secreted proteomes of a probiotic bacterium provide candidate proteins for intestinal attachment and communication with the host. Proteomics. 17(11). doi: 10.1002/pmic.201700112. PMID: 28517912
C. J. Jeffery. (2017) Moonlighting Proteins In Bacteria. in Moonlighting Proteins: Novel Virulence Factors in Bacterial Infection. (B. Henderson, Ed.) Springer (Netherlands). In Press.
W. Wang and C. J. Jeffery. (2016) An Analysis of Surface Proteomics Results Reveals Novel Candidates for Intracellular/Surface Moonlighting Proteins in Bacteria. Mol Biosyst. 2016 Apr 26;12(5):1420-31. doi: 10.1039/c5mb00550g. PMID: 26938107
C. J. Jeffery. (2016) Expression, Solubilization and Purification of Bacterial Membrane Proteins. Current Protocols in Protein Science. 83:29.15.1-29.15.15. doi: 10.1002/0471140864.ps2915s83
C. J. Jeffery. (2016) Protein Species and Moonlighting Proteins: Very Small Changes in a Protein’s Covalent Structure Can Change its Biochemical Function. Journal of Proteomics. pii: S1874-3919(15)30146-9. doi: 10.1016/j.jprot.2015.10.003.
Mani, M. C. Chen, V. Amblee, H. Liu, T. Mathur, G. Zwicke, S. Zabad, B. Patel, J. Thakkar, and C. J. Jeffery. (2015) Moonlighting Proteins Database (MoonProt): A database of proteins that are known to moonlight. Nucleic Acids Research. 43: D277–D282. doi: 10.1093/nar/gku954. PMID: 25324305
Jeffery, C. J. (2015) Pancreatic Cancer, Islet Cell. in The SAGE Encyclopedia of Cancer and Society, Second Edition, editors Colditz, Graham A., Golson, J. Geoffrey. SAGE Publications, Inc. Thousand Oaks, California. pp 891-893 http://dx.doi.org/10.4135/9781483345758.n438
C. J. Jeffery. (2015) Why Study Moonlighting Proteins? Frontiers in Genetics. Research Topic on Moonlighting Proteins. 6:211. doi:10.3389/fgene.2015.00211. PMID: 26150826
Amblee, V. and C. J. Jeffery. (2015) Physical Features of Intracellular Proteins that Moonlight on the Cell Surface. PLOS One. 10(6):e0130575. doi: 10.1371/journal.pone.0130575. eCollection 2015. PMID: 26110848
Jeffery, C. J. (2015) Lung Cancer, Small Cell. in The SAGE Encyclopedia of Cancer and Society, Second Edition, editors Colditz, Graham A., Golson, J. Geoffrey. SAGE Publications, Inc. Thousand Oaks, California. pp 697-698. http://dx.doi.org/10.4135/9781483345758.n339
Jeffery, C. J. (2014) An Introduction to Moonlighting Proteins. Biochemistry Society Transactions. 42(6):1679-1683.
Jeffery C.J. (2013) "New Ideas on Moonlighting", in Moonlighting Cell Stress Proteins in Microbial Infections (B. Henderson, Ed.) Springer (Netherlands). ISBN: 978-94-007-6786-7 (Print) 978-94-007-6787-4 (Online) doi. 10.1007/978-94-007-6787-4. pp. 51-66.
Zwicke, G. L., G. A. Mansoori and C. J. Jeffery. (2012) Utilizing the Folate Receptor for Active Targeting of Cancer Nanotherapeutics. Nano Rev. 2012;3. doi: 10.3402/nano.v3i0.18496. PMID: 23240070
Jeffery, C. J. (2012) Workshop Attendees Suggest Methods to Improve the Number and Advancement of Women Scientists in Nanoscience/Nanotechnology. Nano Reviews. 3: 15895. (News Article for “Nano News and Nano Views” section in Nano Reviews)
Jeffery, C. J. (2012) Danish Team wins First BIOMOD International Undergraduate Nanobiology Design Competition. Nano Reviews. 3: 17201. (News Article for “Nano News and Nano Views” section in Nano Reviews)
Roux, C., F. Bhatt, J. Foret, B. de Courcy, N. Gresh, J.-P. Piquemal, C. J. Jeffery, and L. Salmon. (2011) The reaction mechanism of type I phosphomannose isomerases: new information from inhibition and polarizable molecular mechanics studies.
Proteins: Structure, Function, and Bioinformatics 79: 203-220.
Jeffery, C. J. (2011) Proteins with Neomorphic Moonlighting Functions in Disease. IUBMB Life (Special issue with the topic Moonlighting Proteins in Neurological Disorders). 63(7): 489-94.
Jeffery, C. J. (2011) Engineering Perplasmic Binding Proteins as Glucose Nanosensors. Nano Reviews 2: 5743-6. doi: 10.3402/nano.v2i0.5743. PMID: 22110874.
Bhatt, F. and C. J. Jeffery (2010) Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein. J Vis Exp. Dec 3;(46). pii: 2134. doi: 10.3791/2134.
Madhavan, V, F. Bhatt, and C. J. Jeffery. (2010) Recombinant expression screening of P. aeruginosa bacterial inner membrane proteins. BMC Biotechnol. 10:83.
Arsenieva, D., B. L. Appavu, G. Mazock, and C. J. Jeffery. (2009) X-ray Crystal Structure of Trypanosoma brucei Phosphoglucose Isomerase Complexed with Glucose-6-phosphate at 1.6 Å Resolution. Proteins: Structure, Function, and Bioinformatics 74:72-80
Jeffery, C. J. (2009) Moonlighting Proteins - An Update. Molecular Biosystems. 5:345-50.
Jeffery, C. J. (2007) Review of New and Emerging Proteomic Techniques by Dobrin Nedelko and Randall W. Nelson. J Am Soc Mass Spectrom 18:162–164.
Jeffery, C. J. (2005) Mass Spectrometry and the Search for Moonlighting Proteins. Mass Spectrometry Reviews. 24:772-82.
Jeffery, C. J. (2005) Moonlighting Proteins: Proteins with Multiple Functions. In The Extracellular Biology of Molecular Chaperones. Edited by Brian Henderson and A. Graham Pockley. Cambridge University Press. New York. Pp. 61-77.
Lee, J.H. and C. J. Jeffery. (2005) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with D-Sorbitol-6-phosphate, an Analog of the Open Chain Form of D-glucose-6-phosphate. Protein Science. 14: 727-34.
Jeffery, C. J. (2004) Moonlighting Proteins: Complications and Implications for Proteomics Research. Drug Discovery Today Targets. 3: 71-78.
Jeffery, C. J. (2004) Molecular Mechanisims of Multitasking: Recent Crystal Structures of Moonlighting Proteins. Current Opinion in Structural Biology. 14: 663-8.
Roux, C., J. H. Lee, C. J. Jeffery, and L. Salmon. (2004) Inhibition of type I and type II Phosphomannose Isomerases by the Reaction Intermediate Analogue 5‑phospho-D-arabinonohydroxamic Acid Supports a Catalytic Role for the Metal Cofactor. Biochemistry. 43: 2926-34.
Jeffery, C. J. (2003) Moonlighting Proteins: Old Proteins Learning New Tricks. Trends in Genetics. 19: 415-7.
Jeffery, C. J. (2003) Multifunctional Proteins: Examples of Gene Sharing. Annals of Medicine. 35: 28-35.
Arsenieva, D. and C. J. Jeffery. (2002) Conformational Changes in Phosphoglucose Isomerase Induced by Ligand Binding. Journal of Molecular Biology. 323: 77-84
Arsenieva, D., R. Hardré, L. Salmon, and C. J. Jeffery. (2002) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with 5-phospho-D-arabinonhydroxamate. Proc. Nat. Acad. Sci., USA. 99: 5872-7.
Lee, J.H., K.Z. Chang, V. Patel, and C. J. Jeffery (2001) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with its Substrate, D-Fructose 6-Phosphate. Biochemistry, 40:7799-805.
Jeffery, C. J., R. Hardré, and L. Salmon. (2001) The Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with 5-Phospho-D-Arabinonate Identifies the Role of Glu357 in Catalysis. Biochemistry. 40: 1560-6.
Jeffery, C. J., B. Bahnson, W. Chien, D. Ringe, and G. A. Petsko. (2000) Crystal Structure of Rabbit Phosphoglucose Isomerase, a Glycolytic Enzyme that Moonlights as Neuroleukin, Autocrine Motility Factor, and Differentiation Mediator. Biochemistry. 39: 955-64.
Jeffery, C. J., L.M. Gloss, G. A. Petsko, and D. Ringe. (2000) The Role of Resides Outside of the Active Site in Catalysis: Structural basis for function of C191 mutants of E. coli Aspartate Aminotransferase. Protein Engineering. 13: 105-12.
Jeffery, C. J. Moonlighting Proteins. (1999) Trends in Biochemical Sciences. 24: 8-11.
Jeffery, C. J. and D. E. Koshland, Jr. (1999) The E. coli Aspartate Receptor: Sequence Specificity of a Transmembrane Helix Studied by Hydrophobic-Biased Random Mutagenesis. Protein Engineering. 12: 863-72.
Jeffery, C. J., T. Barry, S. Doonan, G. A. Petsko, and D. Ringe. (1998) Crystal Structure of Saccharomyces cerevisiae Cytosolic Aspartate Aminotransferase. Protein Science. 7: 1380-7.
Jeffery, C. J., T. Barry, S. Doonan, G. A. Petsko, and D. Ringe. (1998) Crystallization and Preliminary X-ray Diffraction Analysis of S. cerevisiae Aspartate Aminotransferase. Acta Cryst D54: 659-61.
Jeffery, C. J. and D. E. Koshland, Jr. (1994) A Single Hydrophobic to Hydrophobic Substitution in the Transmembrane Domain Impairs Aspartate Receptor Function. Biochemistry. 33: 3457-63.
Jeffery, C. J. and D. E. Koshland, Jr. (1993) Vibrio cholerae hlyB is a Member of the Chemotaxis Receptor Gene Family. Protein Science. 2: 1532-5.
Jeffery, C. J. and D. E. Koshland, Jr. (1993) Three-dimensional Structural Model of the Serine Receptor Ligand-Binding Domain. Protein Science. 2: 559-66.
Lynch, B. A., C. J. Jeffery, H.-P. Biemann, and D. E. Koshland, Jr. (1992) Transmembrane Signaling in the Bacterial Aspartate Receptor. Proceedings of the Robert A. Welch Foundation Conference on Chemical Research. XXXVI.
